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P-gp is a 170 kDa transmembrane glycoprotein, which includes 10–15 kDa of N-terminal glycosylation.The N-terminal half of the protein contains six transmembrane helixes, followed by a large cytoplasmic domain with an ATP-binding site, and then a second section with six transmembrane helixes and an ATP-binding domain that shows over 65% of amino acid similarity with the first half of the ...
While leading a group of WSU researchers, she discovered that a gene mutation called MDR1 predisposed herding dogs—collies to react violently to a deworming pill. Based on this discovery, Mealey developed a clinical test for the mutation based on blood samples and cheek swabs from at least 25 unrelated dogs of every one of the 150-plus breeds.
Acepromazine, acetopromazine, or acetylpromazine (commonly known as ACP, Ace, or by the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during the 1950s as an antipsychotic, [4] but is now almost exclusively used on animals as a sedative and antiemetic.
dexamethasone – anti-inflammatory steroid. diazepam – benzodiazepine used to treat status epilepticus, also used as a preanaesthetic and a sedative. dichlorophene – fungicide, germicide, and antimicrobial agent, also used for the removal of parasites. diphenhydramine – histamine blocker. doxycycline – antibiotic, also used to treat ...
[30] [52] [92] Since dogs with diabetes are prone to pancreatitis and hyperlipidemia, feeding a low-fat food may help limit or avoid these complications. [64] [34] A non-prescription food with a "fixed formula" would be suitable because of the consistency of its preparation. Fixed formula foods contain precise amounts of their ingredients so ...
Zinc phosphide is a combination of phosphorus and zinc. If ingested, the acid in a dog's stomach turns the compound into phosphine, which is a toxic gas. The phosphine gas crosses into the dog's cells and causes the cell to die. Signs of poisoning include vomiting, anxiety, and loss of coordination.
Multiple drug resistance. Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories. [1] Antimicrobial categories are classifications of antimicrobial agents based on their mode of action and ...
Oclacitinib. Oclacitinib, sold under the brand name Apoquel among others, is a veterinary medication used in the control of atopic dermatitis and pruritus from allergic dermatitis in dogs at least 12 months of age. [1][4] Chemically, it is a synthetic cyclohexylamino pyrrolopyrimidine janus kinase inhibitor that is relatively selective for JAK1 ...