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In an ultra-high-shear inline mixer, the high-shear mixing takes place in a single or multiple passes through a rotor–stator array. The mixer is designed to subject the product to higher shear and a larger number of shearing events than a standard inline rotor–stator mixer, producing an exceptionally narrow particle-size distribution.
The Scherrer equation, in X-ray diffraction and crystallography, is a formula that relates the size of sub-micrometre crystallites in a solid to the broadening of a peak in a diffraction pattern. It is often referred to, incorrectly, as a formula for particle size measurement or analysis. It is named after Paul Scherrer.
A high level of hydraulic shear [clarify] stress is applied on the fluid which results in disrupting and breaking down the structure. Colloid mills are frequently used to increase the stability of suspensions and emulsions, but can also be used to reduce the particle size of solids in suspensions. [1]
It has since been used in other applications such as cell disruption nanoemulsions, and solid particle size reduction, among others. By using microchannels with fixed geometry, and an intensifier pump, high shear rates are generated that rupture the cells. This method of cell lysis can yield breakage of over 90% of E. coli cells.
Particle size, Grain size, Size distribution, Morphology: Methods and techniques; ... (in a high-shear granulator), screws (in a twin screw granulator) ...
The nondimensionalization is in order to compare the driving forces of particle motion (shear stress) to the resisting forces that would make it stationary (particle density and size). This dimensionless shear stress, τ ∗ {\displaystyle \tau *} , is called the Shields parameter and is defined as: [ 12 ]
Different formulation procedures include high shear homogenization ... Obtaining size distributions in the range of 30-180 nm is possible using ... particle size, ...
The particle size measurement is typically achieved by means of devices, called Particle Size Analyzers (PSA), which are based on different technologies, such as high definition image processing, analysis of Brownian motion, gravitational settling of the particle and light scattering (Rayleigh and Mie scattering) of the particles.
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