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[118] [119] Complicating the use of aspirin for prevention is the phenomenon of aspirin resistance. [120] [121] For people who are resistant, aspirin's efficacy is reduced. [122] Some authors have suggested testing regimens to identify people who are resistant to aspirin. [123]
An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]
Lysine acetylsalicylate, also known as aspirin DL-lysine or lysine aspirin, is a more soluble form of acetylsalicylic acid (aspirin). As with aspirin itself, it is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antithrombotic and antipyretic properties. [ 1 ]
Calpol was launched in 1959 by English pharmaceutical company, Calmic Ltd, based in Crewe, Cheshire; the company's name was an abbreviation of Cheshire and Lancashire Medical Industries Corporation, which moved from Lancashire to Crewe Hall in 1947. [5] The Calpol brand name is likely a combination of 'Calmic' and 'paracetamol'. [6]
It is used in medicine as an analgesic and antipyretic. [6] Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [7] [8] [9] and also necrosis. [10] It is also a potential replacement for aspirin for people sensitive to it.
Spirea ulmaria (now known as Filipendula ulmaria), or meadowsweet, is the German namesake of Spirsäure (salicylic acid), and ultimately aspirin. The name Aspirin was derived from the name of the chemical ASA—Acetylspirsäure in German. Spirsäure (salicylic acid) was named for the meadowsweet plant, Spirea ulmaria, from which it could be ...
[55] [56] PPIs are commonly used in people with cardiovascular disease for gastric protection when aspirin is given for its antiplatelet actions. [ 55 ] [ 57 ] An interaction between PPIs and the metabolism of the platelet inhibitor clopidogrel is known and this drug is also often used in people with cardiac disease.