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Progressive retinal atrophy (PRA) is a group of genetic diseases seen in certain breeds of dogs and, more rarely, cats. Similar to retinitis pigmentosa in humans, [ 1 ] it is characterized by the bilateral degeneration of the retina , causing progressive vision loss culminating in blindness.
The retinal degeneration appears to be related to apoptosis of these cells. [11] SARDS must be distinguished from other causes of sudden blindness that have no visible pathology, including retrobulbar optic neuritis , a tumor at the optic chiasm , or other central nervous system diseases.
One such condition is progressive retinal atrophy, or PRA, which affects the light-sensitive cells at the back of the eye. It affects over 100 breeds, can be caused by multiple different genetic ...
Cataracts typically occur when proteins break down in the lens of a dog's eye and clump together, obstructing the passage of light. [1] [2] There are several reasons cataracts may occur in dogs, such as heredity, trauma, aging, diabetes, glaucoma, and progressive retinal atrophy.
Collie eye anomaly (CEA) is a congenital, inherited, bilateral eye disease of dogs, which affects the retina, choroid, and sclera. It can be a mild disease or cause blindness. CEA is caused by a simple autosomal recessive gene defect. There is no treatment.
Similar to rd1 in mice, Rod-cone dysplasia type 1 (rcd1-PRA) is a form of progressive retinal atrophy (PRA), with early onset of the disease. The Irish Setter is a characterized animal model of rcd1. The mutation is caused by a nonsense mutation in pde6b gene. Photoreceptors start degeneration at postnatal day 13 until a year after the dog is ...
Eye disorders (e.g., cataracts, progressive retinal atrophy) Blood disorders (e.g., von Willebrand disease) Brachycephalic syndrome (respiratory issues in flat-faced breeds)
Imperforate lacrimal punctum - Disease in dogs, missing disease in cattle and sheep. Short stub. Iris cyst - Disease in dogs. Stub. Ocular melanosis - Disease in dogs. Short stub. Persistent pupillary membrane - Disease in dogs, short stub. Progressive retinal atrophy - Disease in dogs, cats. Retinal dysplasia - Disease in various species.