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These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
In any case, common side effects of antiandrogens in men include breast tenderness, breast enlargement, feminization, hot flashes, sexual dysfunction, infertility, and osteoporosis. In women, antiandrogens are much better tolerated , and antiandrogens that work only by directly blocking androgens are associated with minimal side effects.
An alpha privative or, rarely, [1] privative a (from Latin alpha prīvātīvum, from Ancient Greek α στερητικόν) is the prefix a-or an-(before vowels) that is used in Indo-European languages such as Sanskrit and Greek and in words borrowed therefrom to express negation or absence, for example the English words of Greek origin atypical, anesthetic, and analgesic.
However, the serotonin receptor antagonism has side effects such as weight gain and impaired movement. [11] Hence, alpha-2 blockers are not used clinically due to its extensive binding. Similar to the alpha-1 blocker, the alpha-2 family will also present the first-dose effect , but it is generally less pronounced compared with the alpha-1 blockers.
Examples of alpha 2 blockers include yohimbine and idazoxan. [2] Apart from being used as antidotes to reverse the overdose effects of alpha 2 agonists, they only have a limited number of indications. [3] For instance, Yohimbine has been used to treat sexual dysfunction in males. [3]
A side effect of phenoxybenzamine is reflex tachycardia. As a non-selective alpha receptor antagonist, it will also affect both the postsynaptic alpha-1 and presynaptic alpha-2 receptors in the nervous system, and so reduce sympathetic activity.
These adverse sexual side effects are typically seen in less than 5% of men on the drug. There is also a link to mental health effects, including depression. However, it’s unclear how common ...
Common side effects include dizziness, headache, insomnia, nausea, blurry vision, and sexual problems. [9] [6] Other side effects may include feeling lightheaded with standing due to changes in blood pressure, and angioedema. [9] Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate. [10]