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Pregnancy Adapted Geneva score [4] Variable (modified items from Revised Geneva score in bold) Score Age 40 (65) years or over: 1 Previous DVT or PE 3 Surgery or lower limb fracture within 1 month 2 Active malignant condition: 2: Unilateral lower limb pain 3 Hemoptysis 2 Heart rate 75 to 94 beats per minute: 3: Heart rate 110 (95) or more beats ...
D-dimer (or D dimer) is a dimer that is a fibrin degradation product (FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two D fragments of the fibrin protein joined by a cross-link , hence forming a protein dimer .
Principles of D-dimer testing. Fibrin degradation products (FDPs), also known as fibrin split products, are components of the blood produced by clot degeneration. [1] Clotting, also called coagulation, at the wound site produces a mass of fibrin threads called a net that remains in place until the cut is healed. As a cut heals, the clotting ...
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MDCalc was founded by two emergency physicians, Graham Walker, MD, and Joseph Habboushe, MD, MBA, [5] and provides over 500 medical calculators and other clinical decision-support tools. [6] The MDCalc.com website was launched in 2005. [5] In 2016, MDCalc launched an iOS app, [7] followed by an Android app in 2017. [8]
In pregnancy, D-dimer is likely to be elevated and loses its use a diagnostic tool. No different normal range is used, because by increasing the cutoff you'd lose its sensitivity. In pregnancy clinical assessment and V/Q scanning is used. JFW | T@lk 19:06, 26 November 2006 (UTC)
An estimate of the required number of Rho(D) immune globulin vials may assume the following equations: [6] Volume (mL) of Fetal Blood = % Fetal Cells x 50; Number of Vials of 300 mcg RhIG Required = Volume of Fetal Blood/30mL; Combining those two equations results in: [6] Number of vials = % Fetal Cells x 50 / 30; This is approximately equal to:
As an example, Alpha-fetoprotein (AFP) testing is used to screen for a neural tube defect (NTD) during the second trimester of pregnancy. If the median AFP result at 16 weeks of gestation is 30 ng/mL and a pregnant woman's AFP result at that same gestational age is 60 ng/mL, then her MoM is equal to 60/30 = 2.0.
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