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  2. Initiator protein - Wikipedia

    en.wikipedia.org/wiki/Initiator_protein

    The initiator proteins are the proteins that recognize a specific DNA sequence within the origin of replication. The origin of replication is the site where the helicase attaches to the template strand and starts to unwind the DNA into two strands.

  3. DnaA - Wikipedia

    en.wikipedia.org/wiki/DnaA

    DnaA is a protein that activates initiation of DNA replication in bacteria. [1] Based on the Replicon Model, a positively active initiator molecule contacts with a particular spot on a circular chromosome called the replicator to start DNA replication. [2] It is a replication initiation factor which promotes the unwinding of DNA at oriC. [1]

  4. Iteron - Wikipedia

    en.wikipedia.org/wiki/Iteron

    The replication initiator protein (Rep) plays a key role in initiation of replication in plasmids. In its monomer form, Rep binds an iteron and promotes replication. The protein itself is known to contain two independent N-terminal and C-terminal globular domains that subsequently bind to two domains of the iteron.

  5. Origin of replication - Wikipedia

    en.wikipedia.org/wiki/Origin_of_replication

    More than five decades ago, Jacob, Brenner, and Cuzin proposed the replicon hypothesis to explain the regulation of chromosomal DNA synthesis in E. coli. [18] The model postulates that a diffusible, trans-acting factor, a so-called initiator, interacts with a cis-acting DNA element, the replicator, to promote replication onset at a nearby origin.

  6. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    [11] [10] In E. coli the primary initiator protein is Dna A; in yeast, this is the origin recognition complex. [27] Sequences used by initiator proteins tend to be "AT-rich" (rich in adenine and thymine bases), because A-T base pairs have two hydrogen bonds (rather than the three formed in a C-G pair) and thus are easier to strand-separate. [28]

  7. Replicon (genetics) - Wikipedia

    en.wikipedia.org/wiki/Replicon_(genetics)

    The initiator is the protein that recognizes the replicator and activates replication initiation. [ 1 ] Sometimes in bacteriology , the term "replicon" is only used to refer to chromosomes containing a single origin of replication and therefore excludes the genomes of archaea and eukaryotes which can have several origins.

  8. NYT ‘Connections’ Hints and Answers Today, Wednesday, December 11

    www.aol.com/nyt-connections-hints-answers-today...

    today's connections game answers for wednesday, december 11, 2024: 1. utopia: paradise, seventh heaven, shangri-la, xanadu 2. things you shake: hairspray, magic 8 ...

  9. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    The major enzymatic functions carried out at the replication fork are well conserved from prokaryotes to eukaryotes, but the replication machinery in eukaryotic DNA replication is a much larger complex, coordinating many proteins at the site of replication, forming the replisome.