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A new study compares ketamine with electroconvulsive therapy in people with treatment-resistant depression. The researchers identify subsets of people who respond better to ketamine and vice versa.
The mechanism of action of ketamine in alleviating depression is not well understood and is an area of active investigation. Due to the hypothesis that NMDA receptor antagonism underlies the antidepressant effects of ketamine, esketamine was developed as an antidepressant. [11]
How does ketamine work as an antidepressant? An FDA-approved anesthetic, ketamine has been recognized as a fast-acting antidepressant drug for decades. The FDA officially approved esketamine, or ...
Ketamine has been demonstrated to produce lasting antidepressant effects after administration in a clinical setting. In 2019, esketamine, an NMDA antagonizing enantiomer of ketamine, was approved for use as an antidepressant in the United States. [17] In 2022, Auvelity was approved by the FDA for the treatment of depression.
A patient can choose between ketamine infusion therapy, where the patient takes a low dose of ketamine each session and sits at the clinic for about an hour; and ketamine-assisted therapy, during ...
Two clinics are using ketamine to treat depression. Is it safe, how does it work and answers to other questions.
Ketamine has been tested as a rapid-acting antidepressant [13] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [14] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [15] [16]
Ketamine therapy primarily treats depression, PTSD, anxiety, suicidality, and other mental health conditions. Most patients return for two follow-up ketamine treatments we refer to as boosters on ...
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