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Clonidine's blood pressure lowering effects are due to stimulation of presynaptic α 2 autoreceptors in the CNS which suppress sympathetic outflow. Mirtazapine itself blocks these same α 2 autoreceptors, so the effect of adding mirtazapine to a patient stabilized on clonidine may precipitate withdrawal symptoms. [75]
Taking medications like blood pressure and lipid-lowering drugs for more than 5 years is associated with a lower incidence of dementia, a new study has found.
Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%, and can reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. [2] There are many classes of antihypertensives, which lower blood pressure by different means.
For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]
Diuretics, which lower blood pressure directly by causing the kidney to produce more urine. Beta-blockers, which slow down the heart and reduce the force of its contractions.
“Regular physical activity can lower blood pressure by 5 to 7 mm Hg,” says Shelley Balls, M.D.A., RDN, LDN, a registered dietitian and nutritionist for Consumer Health Digest.
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