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Ethylene glycol, antifreeze, is extremely toxic to dogs. It has a sweet taste and thus dogs will drink it. As little as 2 1/2 tablespoons can kill a medium-sized dog in 2–3 days. This type of poisoning is often fatal as dog owners do not know their pet has ingested the antifreeze. De-icing fluids can also contain ethylene glycol.
The antidotes for ethylene glycol poisoning are ethanol and fomepizole. This antidotal treatment forms the mainstay of management of ethylene glycol poisoning. The toxicity of ethylene glycol comes from its metabolism to glycolic acid and oxalic acid. The goal of pharmacotherapy is to prevent the formation of these metabolites.
2022 – At least 40 dogs died in Brazil after consuming Bassar produced snacks for dental care [113] that were also sold under the Petz [114] brand. The snacks were contaminated with ethylene glycol, probably originating from contamined propylene glycol. All products made by Bassar were recalled on the 7th of September. [113]
Fomepizole is used to treat ethylene glycol and methanol poisoning. It acts to inhibit the breakdown of these toxins into their active toxic metabolites. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase, [6] found in the liver. This enzyme plays a key role in the metabolism of ethylene glycol, and of methanol.
Tristian Paul Pearson, who left out tubs of tuna alced with ethylene glycol - which is highly poisonous to cats - was sentenced at Cardiff Crown Court. Wales: Man admits feeding poisoned tuna to ...
6. Worms and other parasitic infections. With heavy worm burdens or certain parasitic infections, dogs can vomit. You may see worms in the vomit, but an absence of worms doesn’t mean parasites ...
A client of Riser Animal Hospital in Des Plaines brought in at least seven pieces of hot dogs injected with rat poison. The client said they found the hot dogs in several front yards.
The effect of ethanol on dogs and cats is similar to its effect on humans, also causing intoxication. Death is unlikely given supportive care (only one death is known). Ethanol is also an antidote for ethylene glycol poisoning. [47] Mouse and rat poison, anticoagulant type Rodenticide is commonly found in the house or garage.