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Flea bites allow for the bacteria to pass the skin barrier. Y. pestis expresses a plasmin activator that is an important virulence factor for pneumonic plague and that might degrade on blood clots to facilitate systematic invasion. [19] Many of the bacteria's virulence factors are antiphagocytic in nature.
The treatment of choice is penicillin, and the duration of treatment is around 10 days. [23] Antibiotic therapy (using injected penicillin) has been shown to reduce the risk of acute rheumatic fever. [24] In individuals with a penicillin allergy, erythromycin, other macrolides, and cephalosporins have been shown to be effective treatments. [25]
If the bacteria happen to enter the bloodstream rather than the lymph or lungs, they multiply in the blood, causing bacteremia and severe sepsis. In septicemic plague, bacterial endotoxins cause disseminated intravascular coagulation (DIC), where tiny blood clots form throughout the body, commonly resulting in localised ischemic necrosis ...
For this reason, blood cultures must be drawn with great attention to sterile process. The presence of certain bacteria in the blood culture, such as Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli almost never represent a contamination of the sample.
Penicillin can easily enter bacterial cells in the case of Gram-positive species. This is because Gram-positive bacteria do not have an outer cell membrane and are simply enclosed in a thick cell wall. [45] Penicillin molecules are small enough to pass through the spaces of glycoproteins in the cell wall.
Ampicillin/sulbactam has a wide array of medical use for many different types of infectious disease. It is usually reserved as a second-line therapy in cases where bacteria have become beta-lactamase resistant, rendering traditional penicillin-derived antibiotics ineffective.
Since the blood clots now completely covered my lungs, the X-ray showed no contrast." The x-ray didn't show a contrast, but his Apple Watch was still on high alert, telling him his blood oxygen ...
Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (). [6] Symptoms of a PE may include shortness of breath, chest pain particularly upon breathing in, and coughing up blood. [1]
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