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Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. [1] [2] They are found bound to the outer membrane of mitochondria in most cell types of the body.
4129 109731 Ensembl ENSG00000069535 ENSMUSG00000040147 UniProt P27338 Q8BW75 RefSeq (mRNA) NM_000898 NM_172778 RefSeq (protein) NP_000889 NP_766366 Location (UCSC) Chr X: 43.77 – 43.88 Mb Chr X: 16.58 – 16.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Monoamine oxidase B (MAO-B) is an enzyme that in humans is encoded by the MAOB gene. The protein encoded by this gene belongs ...
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Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene. [ 5 ] [ 6 ] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines , such as norepinephrine , serotonin and tyramine .
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Perched up against the edge of a cliff in China’s southwest Guizhou province is the bamboo shack 21-year-old “retiree” Liu Youwen built from scratch.
MAO-A inhibition reduces the breakdown of primarily serotonin, norepinephrine, and dopamine; selective inhibition of MAO-A allows for tyramine to be metabolised via MAO-B. [43] Agents that act on serotonin, if taken with another serotonin-enhancing agent, may result in a potentially fatal interaction called serotonin syndrome; if taken with ...