Search results
Results from the WOW.Com Content Network
MTHFR is the rate-limiting enzyme in the methyl cycle, which includes the conversion of homocysteine into methionine. Defects in variants of MTHFR can therefore lead to hyperhomocysteinemia. [9] There are two common variants of MTHFR deficiency. In the more significant of the two, the individual is homozygous for the 677T polymorphism.
Methylenetetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene. [5] Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate , a cosubstrate for homocysteine remethylation to methionine .
The signs and symptoms of this disorder appear at an early age, generally childhood or adolescence. The causes of MERRF syndrome are difficult to determine, but because it is a mitochondrial disorder, it can be caused by the mutation of nuclear DNA or mitochondrial DNA . [ 3 ]
If the person keeps standing still for longer, rather than restoring circulation in the leg muscles (e.g. by sitting down, walking, or cycling), the ammonia, produced by the amplified residual AMPD activity, may accumulate in the muscle cells and in the surrounding tissues to toxic levels, and may also indirectly affect other organs.
The leg is swollen and red due to venous outflow obstruction. The most common conditions associated with thrombophilia are deep vein thrombosis (DVT) and pulmonary embolism (PE), which are referred to collectively as venous thromboembolism (VTE). DVT usually occurs in the legs, and is characterized by pain, swelling and redness of the limb.
lutants.4 Moreover, children have little or no choice about where they live or go to school. Childhood is a critical period for brain forma-tion. Researchers have shown that children ex-posed to air pollution perform worse on cogni-tive functioning tests6 and have impaired neurological function7–9 and lower IQ scores10 compared with other ...
Most women don’t know four crucial symptoms of breast cancer, according to a new survey. (Getty Images/iStockphoto) Most women can’t identify common symptoms of breast cancer that aren’t ...
Signs and symptoms of CVI in the leg include the following: Varicose veins; Itching ; Hyperpigmentation; Phlebetic lymphedema [7] Chronic swelling of the legs and ankles; Leg ulcer; CVI in the leg may cause the following: Venous stasis; Venous ulcers [8] Stasis dermatitis, [8] also known as varicose eczema