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Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug. They may be mild or severe and may or may not require medical intervention. Some reactions may appear immediately after injection, and some may be delayed. [1] Such reactions can occur with subcutaneous, intramuscular, or intravenous administration.
Common side effects include low blood sugar, nausea, dizziness, abdominal pain, and pain at the site of injection. [6] [10] Gastrointestinal side-effects tend to be strongest at the beginning of treatment period and subside over time. [10] Other serious side effects may include angioedema, pancreatitis, gallbladder disease, and kidney problems. [6]
Subcutaneous injection sites. Commonly used injection sites include: [3]: 723 The outer area of the upper arm. The abdomen, avoiding a 2-inch circle around the navel. The front of the thigh, between 4 inches from the top of the thigh and 4 inches above the knee. The upper back. The upper area of the buttock, just behind the hip bone.
Side effects include minor pain, swelling, and bruises at the injection site. The muscle-freezing effects last about three to five months. ... Side effects can include bruising, redness, swelling ...
Injection site pain: 86%. Fatigue: 62%. Headache: 59%. Muscle pain: 50%. Joint pain: 42%. Chills: 40%. Injection arm swelling or tenderness: 25%. Moderna also included safety data in its ...
But some research has noted rare but serious side effects of once-weekly, 2.4-milligram (mg) semaglutide injections, such as pancreatitis, acute kidney injury, gallbladder issues, and thyroid cancer.
The injection site must be cleaned before administering the injection, and the injection is then administered in a fast, darting motion to decrease the discomfort to the individual. The volume to be injected in the muscle is usually limited to 2–5 milliliters, depending on injection site. A site with signs of infection or muscle atrophy ...
The coagulation cascade.. Warfarin necrosis usually occurs three to five days after drug therapy is begun, and a high initial dose increases the risk of its development. [3]: 122 Warfarin-induced necrosis can develop both at sites of local injection and - when infused intravenously - in a widespread pattern.
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