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Aesthetic flat closure is the surgical work required to produce a smooth flat chest wall contour after the removal of one or both breasts, including obliteration of the inframammary fold and excision of excess lateral tissue (to avoid "dog ears.") [17] [18] It is defined by the National Cancer Institute as the following: "A type of surgery that ...
Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
The Journal of the National Comprehensive Cancer Network, established in 2003, is a monthly peer-reviewed medical journal of oncology and the official journal of the National Comprehensive Cancer Network (NCCN). It is published by Harborside Press and the editor-in-chief is Margaret Tempero (UCSF Helen Diller Family Comprehensive Cancer Center ...
The National Comprehensive Cancer Network (NCCN) is an alliance of 33 [1] cancer centers in the United States, most of which are designated by the National Cancer Institute (one of the U.S. National Institutes of Health) as comprehensive cancer centers. It is a non-profit organization with offices in Plymouth Meeting, Pennsylvania.
The National Comprehensive Cancer Network (NCCN) guidelines recommend bilateral prophylactic mastectomy and bilateral salpingo-oophorectomy for women who are carriers of germline BRCA1/2 mutation. At the age of 35 to 40 years, or once childbearing is completed, the procedure is recommended for risk reduction purposes.
Molecular classification of breast cancer from mRNA expression profiles. DNA microarrays have compared normal cells to breast cancer cells and found differences in the expression of hundreds of genes. Although the significance of many of those genetic differences is unknown, independent analyses by different research groups has found that ...
Histopathologic types of breast cancer, with relative incidences and prognoses. "Lobular carcinoma in situ" is at right. LCIS is identified in 0.5% to 1.5% of benign breast biopsies. These biopsies are often done in response to suspicious mammographic findings, as discussed in the Diagnosis section of this article.
The major concerns regarding this update is whether breast cancer mortality has truly been increasing and if there is new evidence that the benefits of mammography are increasing. [93] According to National Vital Statistics System, mortality from breast cancer has been steadily decreasing in the United States from 2018 to 2021. There have also ...
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