enow.com Web Search

Search results

  1. Results from the WOW.Com Content Network
  2. Thymocyte - Wikipedia

    en.wikipedia.org/wiki/Thymocyte

    Negative selection is not 100% effective, some autoreactive T cells escape thymic censorship, and are released into the circulation. Additional mechanisms of peripheral tolerance active in the periphery exist to silence these cells such as anergy , deletion, and regulatory T cells .

  3. T cell - Wikipedia

    en.wikipedia.org/wiki/T_cell

    T cells are grouped into a series of subsets based on their function. CD4 and CD8 T cells are selected in the thymus, but undergo further differentiation in the periphery to specialized cells which have different functions. T cell subsets were initially defined by function, but also have associated gene or protein expression patterns.

  4. Cortical thymic epithelial cells - Wikipedia

    en.wikipedia.org/wiki/Cortical_thymic_epithelial...

    Major function of cTECs is to positively select those T cells that are capable to recognize and interact with MHC molecules on their surface [3]. Once T cell precursors enter the thymic cortex, they start their transformation from double negative stages (T cell without surface expression of CD4 and CD8 co-receptors) to a double positive stage (T cell with surface expression of both co ...

  5. Medullary thymic epithelial cells - Wikipedia

    en.wikipedia.org/wiki/Medullary_thymic...

    A figure depicting the process of T cell / thymocyte positive and negative selection in the thymus. mTEC shown in orange. Medullary thymic epithelial cells (mTECs) represent a unique stromal cell population of the thymus which plays an essential role in the establishment of central tolerance.

  6. Thymus - Wikipedia

    en.wikipedia.org/wiki/Thymus

    The thymus (pl.: thymuses or thymi) is a specialized primary lymphoid organ of the immune system.Within the thymus, thymus cell lymphocytes or T cells mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders.

  7. Central tolerance - Wikipedia

    en.wikipedia.org/wiki/Central_tolerance

    T cell receptors with sufficient affinity for peptide-MHC complexes are selected for survival. Depending on whether the T cell binds MHC I or II, it will become a CD8+ or CD4+ T cell, respectively. Positive selection occurs in the thymic cortex with the help of thymic epithelial cells that contain surface MHC I and MHC II molecules.

  8. Antigen transfer in the thymus - Wikipedia

    en.wikipedia.org/wiki/Antigen_transfer_in_the_thymus

    Antigen transfer in the thymus is the transmission of self-antigens between thymic antigen-presenting cells which contributes to the establishment of T cell central tolerance. [ 1 ] Thymus represents an origin of T cell development and its responsibility is to select functional but also safe T cells which will not attack self tissues.

  9. Thymic epithelial cell - Wikipedia

    en.wikipedia.org/wiki/Thymic_epithelial_cell

    The thymic microenvironment is established by TEC network filled with thymocytes (blood cell precursors of T cells) in different developing stages. TECs and thymocytes are the most important components in the thymus, that are necessary for production of functionally competent T lymphocytes and self tolerance .