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In patients with significantly impaired liver function (Child-Pugh score B and C), the serum half-life is increased to 3 to 8 hours. Praziquantel and its metabolites are mainly excreted renally; within 24 h after a single oral dose, 70 to 80% is found in urine, but less than 0.1% as the unchanged drug.
Oxamniquine, sold under the brand name Vansil among others, is a medication used to treat schistosomiasis due to Schistosoma mansoni. [1] Praziquantel, however, is often the preferred treatment. [2] It is given by mouth and used as a single dose. [2] Common side effects include sleepiness, headache, nausea, diarrhea, and reddish urine. [1]
Anthelmintic medication is also used in mass deworming campaigns of school-aged children in many developing countries. [ 2 ] [ 3 ] Anthelmintics are also used for mass deworming of livestock. The drugs of choice for soil-transmitted helminths are mebendazole and albendazole ; [ 4 ] for schistosomiasis and tapeworms it is praziquantel .
Arpraziquantel ((R)-praziquantel) is the eutomer (the biologically active enantiomer) of praziquantel, and is a medication which is currently under investigation for the treatment of schistosomiasis in young children since it has less side effects than the usual racemic mixture formulation of praziquantel.
It contains esafoxolaner, an aryl isoxazoline; eprinomectin, an avermectin anthelmintic; and praziquantel, a pyrazinoisoquinoline anthelmintic. [ 3 ] Veterinary uses
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Schistosomiasis is treatable by taking a single dose of the drug praziquantel by mouth annually. [66] Praziquantel eliminates the adult schistosomes but does not kill the eggs and immature worms. [19] Live eggs can be excreted by the infected individuals for weeks after treatment with praziquantel. [19]
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