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The consensus recommendation appears to be to avoid prolonged use of paracetamol in pregnancy and use it only when necessary, at the lowest effective dosage, and for the shortest time. [82] [102] [103] In pregnancy, paracetamol and metoclopramide are deemed safe as are NSAIDs until the third trimester. [104]
In contrast, paracetamol (acetaminophen) is regarded as being safe and well tolerated during pregnancy, but Leffers et al. released a study in 2010, indicating that there may be associated male infertility in the unborn. [92] [93] Doses should be taken as prescribed, due to risk of liver toxicity with overdoses. [94]
Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Enoxaparin is listed as Pregnancy Category B, meaning animal studies have failed to show harmful effects to the fetus and therefore are safe to use in pregnant women. [ 37 ] [ 39 ] However, pregnant women taking LMWH may not experience the full anticoagulant effect due to the nature of the medication compared to other anticoagulants (i.e ...
New research has revealed that a common medication might not be safe for everyone. Acetaminophen, brand name Tylenol, is a pain reliever and fever reducer that's often included in other drugs ...
It appears to be safe in pregnancy. [9] For paracetamol overdose, it works by increasing the level of glutathione, an antioxidant that can neutralize the toxic breakdown products of paracetamol. [9] When inhaled, it acts as a mucolytic by decreasing the thickness of mucus. [14]
[14] [15] Paracetamol, either alone or in combination with metoclopramide (an anti-nausea drug), is an effective treatment with a low risk of adverse effects. [16] [17] In pregnancy, paracetamol and metoclopramide are deemed safe as are NSAIDs until the third trimester. [12] Intravenous metoclopramide is also effective by itself. [18] [19]
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