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Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. [6] It is recommended by the World Health Organization (WHO) for the treatment of certain types of epilepsy in developing countries . [ 8 ]
Luminal (phenobarbital) – a barbiturate with sedative and hypnotic properties; R. Remeron (mirtazapine) – an atypical antidepressant, used off-label as a sleep aid;
Corvalol (Корвалол, Corvalolum, Korvalol) is a tranquilizer based on the herb valerian (Valeriana officinalis) root, as well peppermint oil Mentha piperita and hop extract Humulus lupulus and the barbiturate phenobarbital, popular in Eastern Europe and the former Soviet Union as a heart medication. It is available as a transparent ...
Tedral is also composed of phenobarbital, therefore, it is contraindicated for individuals with: [8] [5] [20] Hypersensitivity to phenobarbital, barbiturates or any component of the formulation. A history/manifest or latent porphyria; Liver impairment; Nephritic syndrome (at high dose) A history of sedative-hypnotic drug addiction
Only the phenobarbital group demonstrated a significant change in pain type compared to belladonna alkaloids at the end of the study with an approximate 48% response rate. Patients on Donnatal® tablets, belladonna alkaloids, and placebo all had non-significant (p > 0.149) shifts to dull pain, 39.5%, 52.3%, and 40.4%, respectively compared to ...
It has similar liver enzyme inducing effects to the closely related drug phenobarbital, which may be exploited in some clinical applications. [2] [3] References
There were shortage reports related to phenobarbital from 18 July 2017 to 1 March 2018, disrupting the flow of the production process with quality, time and cost control. With all the factors considered, on 6 June 2018, Bellergal was discontinued by Paladin Labs due to its raw material availability and limited efficacy; while the remaining ...
Phenobarbital reduces the half-life to 4.8 ± 1.3 and increases the clearance by almost 109%. [66] It also interferes with the metabolism of dexamethasone , a synthetic steroid hormone, to the point where its withdrawal from the regimen of a 14-year-old living in the United Kingdom made her hypercortisolemic . [ 67 ]
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