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Dorzolamide is used to lower excessive intraocular pressure in open-angle glaucoma and ocular hypertension.This drug is able to cross the cornea, reach the ciliary body of the eye, and produce systemic effects on the carbonic anhydrase enzyme within the eye.
One key point is that although treatment can help reduce intraocular pressure, which is the only risk factor that can be modified, and early treatment of patients with ocular hypertension has appeared to reduce glaucoma incidence, treatments might not eliminate the possibility of still getting glaucoma.
Acetazolamide is an inhibitor of carbonic anhydrase.It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension, and altitude sickness. For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP.
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.
It is essential older people wear appropriate footwear to reduce their fall risk. Footwear should fit properly and have non-skid, or non-slip, soles. This includes shoes and sneakers, but also ...
Diets rich in four different types of nutrients may help reduce iron buildup in the brain and lower the risk of cognitive decline that comes with aging, a new study suggests. ... later with the ...
Glaucoma is a group of diseases affecting the optic nerve that results in vision loss and is frequently characterized by raised intraocular pressure (IOP). There are many glaucoma surgeries, and variations or combinations of those surgeries, that facilitate the escape of excess aqueous humor from the eye to lower intraocular pressure, and a few that lower IOP by decreasing the production of ...
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