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Skin rash: The most prominent feature is a reddish-purple rash that appears on the lower legs, typically below the knees and above the ankles. The rash is often described as blotchy, mottled, or net-like (reticular in appearance). [6] [7] In some cases, the rash may extend to the dorsum of the feet. [8]
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
Primary pellagra is due to a diet that does not contain enough niacin and tryptophan. [1] Secondary pellagra is due to a poor ability to use the niacin within the diet. [1] This can occur as a result of alcoholism, long-term diarrhea, carcinoid syndrome, Hartnup disease, and a number of medications such as isoniazid. [1]
As with many supplements, there is a possible risk of mild side effects, especially in high doses. These include stomach upset, headache, or skin flushing. NAD injections may cause temporary ...
Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a lipid-lowering agent.It reduces triglyceride levels and increases HDL cholesterol. It may have less marked adverse effects than niacin, although it is unclear whether the recommended dose is as effective as standard doses of niacin.
Gum High-Top. Trying to deadlift 150 pounds in a pair of ancient shoes isn't going to do your ankles any good. The lace-up ankle design gives you a secure fit, while the low-heel drop plants feet ...
Niacin deficiency is a consequence of a diet low in both niacin and the amino acid tryptophan, a precursor for the vitamin. Low plasma tryptophan is a non-specific indicator, meaning it can have other causes. The signs and symptoms of niacin deficiency start to revert within days of oral supplementation with large amounts of the vitamin. [23] [24]
Vitamin D supplements, with or without calcium, are important for overall health. ... An adequate intake of vitamin D may support good immune function and reduce the risk of autoimmune diseases.