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Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems. [ 11 ] [ 16 ] Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and after behavioral changes, such as sleep hygiene , have been tried.
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
Ambien – nonbenzodiazepine used as a sleep aid Anafranil ( clomipramine ) – a tricyclic antidepressant ; mostly used to treat OCD Antabuse ( disulfiram ) – inhibits the enzyme acetaldehyde dehydrogenase , causing acetaldehyde poisoning when ethanol is consumed; used to cause severe hangover when drinking; increases liver, kidney, and ...
Sleeping problems led to an Ambien prescription for Laura Cathcart Robbins. She became addicted to the sleep medication and writes about her recovery. Mom's secret Ambien addiction rocked her ...
Flunitrazepam has a long half-life of 18–26 hours, which means that flunitrazepam's effects after nighttime administration persist throughout the next day. [16] This is due to the production of active metabolites. These metabolites further increase the duration of drug action compared to benzodiazepines that produce nonactive metabolites. [30]
The unchanged drug was 96% bound to plasma proteins. The blood-level decline of the parent drug was biphasic, with the short half-life ranging from 0.4 to 0.6 hours and the terminal half-life from 3.5 to 18.4 hours (mean 8.8 hours), depending on the study population and method of determination. [62]
Eminem broke the hearts of his fans after dropping an emotional music video for his song Temporary on Thursday (October 3). The song, now famous for being dedicated to his daughter and meant to be ...