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Pyrrolizidine alkaloids (PAs), sometimes referred to as necine bases, are a group of naturally occurring alkaloids based on the structure of pyrrolizidine. Their use dates back centuries and is intertwined with the discovery, understanding, and eventual recognition of their toxicity on humans and animals.
E. plantagineum contains pyrrolizidine alkaloids, so is poisonous to nonruminants. [10] [11] When eaten in large quantities, it causes reduced livestock weight, and death in severe cases, due to liver damage. [7] Paterson's curse can also kill horses, [12] and irritate the udders of dairy cows and
Pyrrolizidine alkaloidosis is a disease caused by chronic poisoning found in humans and other animals caused by ingesting poisonous plants which contain the natural chemical compounds known as pyrrolizidine alkaloids. [1] Pyrrolizidine alkaloidosis can result in damage to the liver, kidneys, heart, brain, smooth muscles, lungs, DNA, lesions all ...
Horse chestnut Also known as buckeye [3] Ageratina: Snakeroots Known poisonous species include Ageratina adenophora (Crofton weed, causes Tallebudgera horse disease) and Ageratina altissima (white snakeroot) [3] [12] Aleurites: Tung oil tree [8] Amsinckia intermedia: Fiddleneck Contains pyrrolizidine alkaloids [13] [14] [15] Apocynum cannabinum ...
In earlier feeding trials with horses, consumption led to deaths and symptoms typical of Kimberley horse disease, also known as walkabout disease. These pyrrolizidine alkaloids can also cause damage in liver, lungs and in pigs in the kidney. Additional damage can be done to the liver and lungs and cause dummy syndrome in horses and cattle
Pyrrolizidine is a heterocyclic organic compound. Formally, it is a saturated derivative of pyrrolizine. Pyrrolizidine forms the central chemical structure of a variety of alkaloids known collectively as pyrrolizidine alkaloids. [1] It is one of five classes of iminosugars. These are often synthesized from a carbohydrate. [2]
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E. plantagineum contains pyrrolizidine alkaloids and is poisonous. [2] When eaten in large quantities, it can cause reduced livestock weight or even death. Paterson's curse can kill horses [3] and irritate the udders of dairy cows and the skin of humans. After the 2003 Canberra bushfires, over 40 horses were recorded as put down after eating ...