Search results
Results from the WOW.Com Content Network
Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells. Haematopoiesis (/ h ɪ ˌ m æ t ə p ɔɪ ˈ iː s ɪ s, ˌ h iː m ə t oʊ-, ˌ h ɛ m ə-/; [1] [2] from Ancient Greek αἷμα (haîma) 'blood' and ποιεῖν (poieîn) 'to make'; also hematopoiesis in American English, sometimes h(a)emopoiesis) is the formation of blood cellular ...
Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. [3]
[4] [5] [6] Many people identified as having clonal hematopoiesis have a mutation in a single gene, though a significant number have mutations in two or more genes. [4] [5] [6] The number and variety of observed mutations suggests that these mutations may contribute to clonal hematopoiesis by several distinct mechanisms, discussed in more ...
Hematopoietic stem cells (HSCs) are the stem cells [1] that give rise to other blood cells.This process is called haematopoiesis. [2] In vertebrates, the first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the (midgestational) aorta-gonad-mesonephros region, through a process known as endothelial-to-hematopoietic transition.
Granulopoiesis (or granulocytopoiesis) is a part of haematopoiesis, that leads to the production of granulocytes. A granulocyte , also referred to as a polymorphonuclear leukocyte (PMN), is a type of white blood cell that has multi lobed nuclei , usually containing three lobes, and has a significant amount of cytoplasmic granules within the ...
HUVECs, or endothelial cells isolated from umbilical veins, that were programmed via viral gene manipulation to signal through the Notch and Angiopoietin pathways were found to support and maintain LT-HSCs. [67] Despite the difficulty in isolating sinusoidal ECs, experimental evidence suggests that these cells may play a role in regulating HSCs.
Primitive hematopoiesis occurs in the yolk sac during early embryonic development. It is characterized by the production of primitive nucleated erythroid cells, which is thought to originate from endothelial cells or hemangioblasts, which are capable of forming both endothelium and primitive blood cells.
In humans, the gene RUNX1 is 260 kilobases (kb) in length, and is located on chromosome 21 (21q22.12). The gene can be transcribed from 2 alternative promoters, promoter 1 (distal) or promoter 2 (proximal). As a result, various isoforms of RUNX1 can be synthesized, facilitated by alternative splicing.