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Let's look at the research: People who took the maximum dose of tirzepatide over 72 weeks lost an average of 21 percent of their body weight, according to data from clinical trials published in ...
About 82% of participants taking tirzepatide experienced 5% or greater weight loss. In comparison, only 66.5% of participants taking semaglutide achieved this level of weight loss. Which one to choose
Thursday, Eli Lilly and Company (NYSE:LLY) released topline results from the SUMMIT phase 3 clinical trial evaluating the safety and efficacy of tirzepatide injection (5 mg, 10 mg, or 15 mg) in ...
Tirzepatide is an antidiabetic medication used for the treatment of type 2 diabetes [10] [13] [14] [15] and for weight loss. [11] [16] Tirzepatide is administered via subcutaneous injections (under the skin). [10] [13] It is sold under the brand name Mounjaro for diabetes treatment, [10] and Zepbound for weight loss and treatment of obstructive ...
As of 2022, there is no pathway for approval for drugs that reduce fat mass without 5 percent overall weight loss, even if they significantly improve metabolic health; neither is there one for drugs that help patients maintain weight loss although this can be more challenging than losing weight. [18]
After 40 weeks, people who took tirzepatide had greater reductions in body weight than those who took semaglutide — and the higher the dose, the more weight loss was seen.
The trial was designed to evaluate the efficacy as measured by body weight reduction and other outcomes, safety, and tolerability of two oral doses of azelaprag (300 mg, once or twice daily) in combination with tirzepatide (5 mg subcutaneous injection once weekly). An azelaprag monotherapy arm was included to provide additional safety information.
Preliminary trial results found a greater weight loss compared to either medication alone. HbA1c was significantly improved compared to cagrilintide alone and non-significantly better than semaglutide alone. [1] [2] In a Phase II trial, weight loss averaged -15.6 percent after 32 weeks, making CagriSema comparable in efficacy to tirzepatide.