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The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known. [1] They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.
A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and abdomen). When the same type of tumor is found in the adrenal gland, they are referred to as a pheochromocytoma .
Micrograph highlighting the sustentacular cells in a paraganglioma. S100 immunostain. A sustentacular cell is a type of cell primarily associated with structural support, they can be found in various tissues. [1]
Glomus tumors are usually solitary and small lesions. The vast majority are found in the hand, wrist, foot, and under the fingernails. [3]They are often painful, and the pain is reproduced when the lesion is placed in cold water - a history of sensitivity to cold weather is also common. [6]
6286 n/a Ensembl ENSG00000163993 n/a UniProt P25815 n/a RefSeq (mRNA) NM_005980 n/a RefSeq (protein) NP_005971 n/a Location (UCSC) Chr 4: 6.69 – 6.7 Mb n/a PubMed search n/a Wikidata View/Edit Human S100 calcium-binding protein P (S100P) is a protein that in humans is encoded by the S100P gene. Function The protein encoded by this gene is a member of the S100 family of proteins containing 2 ...
S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a ...
He says Schaetzel told him he believes Floyd died not from asphyxia from Chauvin’s actions, but from complications of a rare tumor called a paraganglioma that can cause a fatal surge of adrenaline.
Paraganglioma (j) typically shows negativity for calcitonin and S100-positive sustentacular cells (inset) [9] Hyperfunctioning follicular adenoma typically shows follicles with papillary infoldings and bubbly, pale colloid with peripheral scalloping (a).