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  2. Factbox-Top Medicare drugs headed for price cuts - AOL

    www.aol.com/news/factbox-top-medicare-drugs...

    Eliquis rival Xarelto from Johnson & Johnson cost Medicare more than $6 billion between June 2022 and May 2023. ... AbbVie and J&J's leukemia treatment Imbruvica cost the federal health plan $2.7 ...

  3. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    The monitoring of warfarin and keeping the international normalized ratio (INR) between 2.0 and 3.0, along with avoiding over and under treatment, has driven a search for an alternative. [3] [14] A naturally occurring inhibitor of factor Xa was reported in 1971 by Spellman et al. from the dog hookworm. [15]

  4. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

  5. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially available in Europe and Canada in 2008. [1] The second one was apixaban (Eliquis), approved in Europe in 2011 [2] and in the United States in 2012. [3] The third one edoxaban (Lixiana, Savaysa) was approved in Japan in 2011 and in Europe and the US in 2015. [4]

  6. Biden administration says Medicare negotiated price discounts ...

    www.aol.com/biden-administration-says-medicare...

    Older Americans on Medicare who take 10 widely prescribed drugs such as Xarelto or Eliquis will get a break on the medications' list prices beginning in 2026. ... Eliquis, a blood thinner from ...

  7. Which cardiovascular drugs may help lower dementia risk? - AOL

    www.aol.com/cardiovascular-drugs-may-help-lower...

    Dementia prevention is a critical area of research, as experts want to understand what people can do to decrease dementia risk. A recent study found that more than 5 years of taking medications ...

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