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High doses of caffeine intake during pregnancy may increase the risk of miscarriage [48] and some major negative pregnancy outcomes, such as stillbirth or low birth weight. [ 49 ] [ 50 ] A 2020 review called into question the safe levels proposed by the European Food Safety Authority, the American Congress of Obstetricians and Gynecologists ...
The metabolism of caffeine is reduced in pregnancy, especially in the third trimester, and the half-life of caffeine during pregnancy can be increased up to 15 hours (as compared to 2.5 to 4.5 hours in non-pregnant adults). [79] Evidence regarding the effects of caffeine on pregnancy and for breastfeeding are inconclusive. [26]
Women are classified as underweight if they have a pre-pregnant BMI of 18.5 or below. [5] Low pre-pregnancy BMI increases the risk of low birth weight infants, but the risk can be balanced by an appropriate gestational weight gain from 12.5 to 18.0 kilograms in total, or about 0.5 kilogram each week in the second and third trimesters. [5]
If pregnant, it is recommended not to consume more than 200 mg of caffeine a day (though this is relative to the pregnant woman’s weight). [26] If a pregnant woman consumes high levels of caffeine, it can result in low birth weight due to loss of blood flow to the placenta, [27] and could lead to health problems later in the child's life. [28]
Estrogen, progesterone, and human chorionic gonadotropin (hCG) levels throughout pregnancy. Estrogen, progesterone, and 17α-hydroxyprogesterone (17α-OHP) levels during pregnancy in women. [ 1 ] The dashed vertical lines separate the trimesters .
Total cortisol increases to three times of non-pregnant levels by the third trimester. [5] The increased estrogen in pregnancy leads to increase corticosteroid-binding globulin production and in response the adrenal gland produces more cortisol. [5] The net effect is an increase of free cortisol.
The health effects of coffee include various possible health benefits and health risks. [1]A 2017 umbrella review of meta-analyses found that drinking coffee is generally safe within usual levels of intake and is more likely to improve health outcomes than to cause harm at doses of 3 or 4 cups of coffee daily.
Intrauterine growth restriction (IUGR), or fetal growth restriction, is the poor growth of a fetus while in the womb during pregnancy.IUGR is defined by clinical features of malnutrition and evidence of reduced growth regardless of an infant's birth weight percentile. [5]
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