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4-Fluoroaniline can be prepared by the hydrogenation of 4-nitrofluorobenzene. [2] It is a common building block in medicinal chemistry and related fields. [3] For example, it is a precursor to the fungicide fluoroimide or the fentanyl analogue parafluorofentanyl. It has also been evaluated for the production of ligands for homogeneous catalysis ...
Fluoroaniline may refer to three compounds with the formula FC 6 H 4 NH 2: 2-Fluoroaniline; 3-Fluoroaniline; 4-Fluoroaniline This page was last edited on 9 February ...
For example, reaction of aniline with sulfuric acid at 180 °C produces sulfanilic acid, H 2 NC 6 H 4 SO 3 H. If bromine water is added to aniline, the bromine water is decolourised and a white precipitate of 2,4,6-tribromoaniline is formed. To generate the mono-substituted product, a protection with acetyl chloride is required:
It is one of three isomeric fluoronitrobenzenes. [2] A yellow oil, it is prepared from 4-nitrochlorobenzene using the Halex process: O 2 NC 6 H 4 Cl + KF → O 2 NC 6 H 4 F + KCl. 4-Fluoronitrobenzene can be hydrogenated to give 4-fluoroaniline, [3] which is a precursor to the fungicide fluoroimide and parafluorofentanyl.
Pauling's second rule is that the value of the first pK a for acids of the formula XO m (OH) n depends primarily on the number of oxo groups m, and is approximately independent of the number of hydroxy groups n, and also of the central atom X. Approximate values of pK a are 8 for m = 0, 2 for m = 1, −3 for m = 2 and < −10 for m = 3. [28]
Contrary to the popular belief, the CF 3 anion, with [K(18-crown-6)] + as a countercation, was produced and characterized by Prakash and coworkers. [55] The challenges associated with observation of CF 3 anion are alluded to its strong basic nature and its tendency to form pentacoordinated silicon species, such as [Me 3 Si(CF 3) 2] − or [Me 3 ...
The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H 3 C – CF 3, and hexafluoroacetone F 3 C –CO– CF 3.
4-Cyano-3-(trifluoromethyl)aniline, also known as 4-amino-2-(trifluoromethyl)benzonitrile, is a cyanated and trifluoromethylated derivative of aniline. It is the starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide .