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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INN Tooltip International Nonproprietary Name), is a naturally occurring psychedelic of the tryptamine family. [5] [1] [4] [2] It is found in a wide variety of plant species, and is also secreted by the glands of at least one toad species, the Colorado ...
[3] [5] [6] On the other hand, 5-MeO-isoDMT has comparable psychoplastogenic potency and effects compared to the psychedelic 5-MeO-DMT. [1] [2] [4] [5] These effects are blocked by the serotonin 5-HT 2A receptor antagonist ketanserin. [4] [5] Certain analogues and derivatives of 5-MeO-isoDMT, like isoDMT and the α-methylated AAZ-A-154 (DLX-001 ...
[161] [163] [164] Similarly to DMT, 5-MeO-DMT is a biased agonist of the serotonin 5-HT 2A receptor, with minimal β-arrestin2 recruitment, and likewise has been associated with little tolerance to its hallucinogenic effects. [165] [140]
5-MeO-DMT is a potent and fast-acting psychedelic, which is naturally produced by the Sonoran Desert toad as well as some species of plants. Its short duration –from 20 minutes to one hour– is ...
5-Methoxytryptamine (5-MT, 5-MeO-T, or 5-OMe-T), also known as serotonin methyl ether or O-methylserotonin and as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. [3] It has been shown to occur naturally in the body in low levels, especially in the pineal gland.
[1] [2] It is the 6-methoxy derivative of the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT. [3] Similarly to analogues like DMT and 5-MeO-DMT, 6-MeO-DMT acts as a serotonin 5-HT 2A receptor agonist as well as a non-selective agonist of many other serotonin receptors.
[1] [2] Several existing psychoplastogens have been identified and their therapeutic effects demonstrated; several are presently at various stages of development as medications including ketamine, MDMA, scopolamine, and the serotonergic psychedelics, including LSD, psilocin (the active metabolite of psilocybin), DMT, and 5-MeO-DMT.
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