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The submucosa (or tela submucosa) is a thin layer of tissue in various organs of the gastrointestinal, respiratory, and genitourinary tracts. It is the layer of dense irregular connective tissue that supports the mucosa ( mucous membrane ) and joins it to the muscular layer , the bulk of overlying smooth muscle (fibers running circularly within ...
Oral submucous fibrosis (OSF) is a chronic, complex, premalignant (1% transformation risk) condition of the oral cavity, characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues (the lamina propria and deeper connective tissues).
Around 800 to 1,000 minor salivary glands are located throughout the oral cavity within the submucosa [12] of the oral mucosa in the tissue of the buccal, labial, and lingual mucosa, the soft palate, the lateral parts of the hard palate, and the floor of the mouth or between muscle fibers of the tongue. [13]
The submucosa consists of a dense and irregular layer of connective tissue with blood vessels, lymphatics, and nerves branching into the mucosa and muscular layer. It contains the submucous plexus , and enteric nervous plexus , situated on the inner surface of the muscular layer.
Duodenal glands are situated within the mucosa and submucosa of the duodenum. They are most abundant near the pylorus, growing shorter and more sparse distally towards the terminal portion of the duodenum. [1] The duodenum can be distinguished from the jejunum and ileum by the presence of Brunner's glands in the submucosa. [citation needed]
A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue.
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Deeper invasion into the submucosa will increase the exposure to lymphatics. [8] Long-standing inflammation is a risk factor for the development of cancer. The lamina propria macrophages when under much stress release pro-inflammatory signals that may lead to increased probability of developing cancer.