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  2. Shiv Kumar Sarin - Wikipedia

    en.wikipedia.org/wiki/Shiv_Kumar_Sarin

    He described two new disease entities; Acute-on-Chronic Liver Failure and Portal biliopathy. He is credited globally to give a large number of new protocols for the management of liver disease patients. His use of growth factors to stimulate bone marrow for liver regeneration as an alternative to liver transplant opened new treatment vistas.

  3. Erythropoiesis-stimulating agent - Wikipedia

    en.wikipedia.org/wiki/Erythropoiesis-stimulating...

    Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. [1] They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS. [1] [2] In these situations they decrease the need for blood transfusions. [2]

  4. Elevated alkaline phosphatase - Wikipedia

    en.wikipedia.org/wiki/Elevated_alkaline_phosphatase

    It serves as a significant indicator for certain medical conditions, diseases and syndromes. [citation needed] If the cause for alkaline phosphatase elevation is unknown, isoenzyme studies using electrophoresis can confirm the source of the ALP. Heat stability also distinguishes bone and liver isoenzymes ("bone burns, liver lasts").

  5. Topoisomerase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Topoisomerase_inhibitor

    Additionally, there has been an increase in observed single point mutations that have shown to prompt TopI resistance to CPT. [37] Therefore, three clinically relevant non-CPT inhibitors, indenoisoquinoline, phenanthridines, and indolocarbazoles, are currently being considered by the FDA as possible chemotherapies. [19]

  6. Pegfilgrastim - Wikipedia

    en.wikipedia.org/wiki/Pegfilgrastim

    Pegfilgrastim is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in people with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia; and to increase survival in people acutely exposed to myelosuppressive doses of radiation (hematopoietic subsyndrome of acute ...

  7. Thrombopoietin - Wikipedia

    en.wikipedia.org/wiki/Thrombopoietin

    Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. [5] Megakaryocytopoiesis is the cellular development process that leads to platelet production.

  8. Hemopoietic growth factor - Wikipedia

    en.wikipedia.org/wiki/Hemopoietic_growth_factor

    Thrombopoietin, another glycoprotein hormone, is produced by the liver and kidneys. It triggers the development of megakaryocytes into platelets. Cytokines are glycoproteins secreted by a wide variety of cells, including red bone marrow, leukocytes, macrophages, fibroblasts, and endothelial cells. They act locally as autocrine or paracrine ...

  9. Erythropoietin - Wikipedia

    en.wikipedia.org/wiki/Erythropoietin

    Erythropoietin (/ ɪ ˌ r ɪ θ r oʊ ˈ p ɔɪ. ɪ t ɪ n,-r ə-,-p ɔɪ ˈ ɛ t ɪ n,-ˈ iː t ɪ n /; [1] [2] [3] EPO), also known as erythropoetin, haematopoietin, or haemopoietin, is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow.