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  2. Zygosity - Wikipedia

    en.wikipedia.org/wiki/Zygosity

    Most eukaryotes have two matching sets of chromosomes; that is, they are diploid. Diploid organisms have the same loci on each of their two sets of homologous chromosomes except that the sequences at these loci may differ between the two chromosomes in a matching pair and that a few chromosomes may be mismatched as part of a chromosomal sex ...

  3. Runs of homozygosity - Wikipedia

    en.wikipedia.org/wiki/Runs_of_Homozygosity

    Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring. [ 1 ] The potential of predicting or estimating individual autozygosity for a subpopulation is the proportion of the autosomal genome above a specified length, termed F ...

  4. Human genome - Wikipedia

    en.wikipedia.org/wiki/Human_genome

    The total length of the human reference genome does not represent the sequence of any specific individual, nor does it represent the sequence of all of the DNA found within a cell. The human reference genome only includes one copy of each of the paired, homologous autosomes plus one copy of each of the two sex chromosomes (X and Y).

  5. Human genetics - Wikipedia

    en.wikipedia.org/wiki/Human_genetics

    The human genome is the total collection of genes in a human being contained in the human chromosome, composed of over three billion nucleotides. [2] In April 2003, the Human Genome Project was able to sequence all the DNA in the human genome, and to discover that the human genome was composed of around 20,000 protein coding genes.

  6. Inbreeding - Wikipedia

    en.wikipedia.org/wiki/Inbreeding

    With continuous inbreeding, genetic variation is lost and homozygosity is increased, enabling the expression of recessive deleterious alleles in homozygotes. The coefficient of inbreeding , or the degree of inbreeding in an individual, is an estimate of the percent of homozygous alleles in the overall genome. [ 69 ]

  7. Human embryonic development - Wikipedia

    en.wikipedia.org/wiki/Human_embryonic_development

    The zygote contains the combined genetic material carried by both the male and female gametes which consists of the 23 chromosomes from the nucleus of the ovum and the 23 chromosomes from the nucleus of the sperm. The 46 chromosomes undergo changes prior to the mitotic division which leads to the formation of the embryo having two cells.

  8. Human genetic variation - Wikipedia

    en.wikipedia.org/wiki/Human_genetic_variation

    The human genome has a total length of approximately 3.2 billion base pairs (bp) in 46 chromosomes of DNA as well as slightly under 17,000 bp DNA in cellular mitochondria. In 2015, the typical difference between an individual's genome and the reference genome was estimated at 20 million base pairs (or 0.6% of the total). [2]

  9. Sequence homology - Wikipedia

    en.wikipedia.org/wiki/Sequence_homology

    Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs). [1] Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. Significant ...