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Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker ...
An FDA-approved weight loss medication, naltrexone-bupropion is generally considered effective and safe to use. You may experience side effects like dizziness, mood changes, trouble sleeping, and ...
[4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4] It is taken by mouth. [4] Both medications have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight. [7]
Bupropion, when used for treating long-term weight gain over six to twelve months, results in an average weight loss of 2.7 kilograms (6.0 lb) over placebo. [74] This is not much different from the weight loss produced by several other weight-loss medications such as sibutramine or orlistat . [ 74 ]
This is where weight loss medication, including weight loss pills, comes in. When combined with diet and exercise, the best weight loss pills can help you lose weight—and keep it off—by:
There are several FDA-approved weight loss drugs, including semaglutide, orlistat, phentermine-topiramate, naltrexone-bupropion and liraglutide. Metformin is another common medication used off ...
Zonegran (zonisamide) – an anticonvulsant used to treat other seizures; Zulresso (brexanolone) – a GABA modulator antidepressant; Zyban (bupropion) – same active ingredient as Wellbutrin, but marketed as a smoking cessation aid; Zyprexa – atypical antipsychotic used to treat schizophrenia and bipolar disorder
“Just as much as the GLP-1s are a diabetes drug and a weight loss medicine, they are brain drugs, too,” says Rekha Kumar, MD, an endocrinologist at New York-Presbyterian and Weill Cornell ...