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The partial pressure of oxygen (pO 2) ... and the prevailing atmospheric pressure 47 mmHg (6.25 kPa) ... for air at sea level at 37 °C. Doubling F i O 2 will ...
Pressure as a function of the height above the sea level. The human body can perform best at sea level, [7] where the atmospheric pressure is 101,325 Pa or 1013.25 millibars (or 1 atm, by definition). The concentration of oxygen (O 2) in sea-level air is 20.9%, so the partial pressure of O 2 (pO 2) is 21.136 kilopascals (158.
The concentration of oxygen (O 2) in air is 20.9% so the partial pressure of O 2 (PO 2) at sea level is about 21.2 kPa (6.3 inHg; 3.07 psi). In healthy individuals, this saturates hemoglobin, the oxygen-binding red pigment in red blood cells. [7]
The atmospheric pressure is roughly equal to the sum of partial pressures of constituent gases – oxygen, nitrogen, argon, water vapor, carbon dioxide, etc.. In a mixture of gases, each constituent gas has a partial pressure which is the notional pressure of that constituent gas as if it alone occupied the entire volume of the original mixture at the same temperature. [1]
This is because a person who is used to living at sea level needs about 0.20 bar (20 kPa; 2.9 psi) partial oxygen pressure to function normally and that pressure can be maintained up to about 40,000 ft (12,192 m) by increasing the mole fraction of oxygen in the air that is being breathed.
The concentration of oxygen in the air (mmols O 2 per liter of air) therefore decreases at the same rate as the atmospheric pressure. [26] At sea level, where the ambient pressure is about 100 kPa, oxygen constitutes 21% of the atmosphere and the partial pressure of oxygen (P O 2) is 21 kPa (i.e. 21% of 100 kPa).
Thus at sea level, where the ambient atmospheric pressure is about 100 kPa, the moistened air that flows into the lungs from the trachea consists of water vapor (6.3 kPa), nitrogen (74.0 kPa), oxygen (19.7 kPa) and trace amounts of carbon dioxide and other gases (a total of 100 kPa). In dry air the partial pressure of O 2 at sea level is 21.0 ...
The alveolar oxygen partial pressure is lower than the atmospheric O 2 partial pressure for two reasons. Firstly, as the air enters the lungs, it is humidified by the upper airway and thus the partial pressure of water vapour (47 mmHg) reduces the oxygen partial pressure to about 150 mmHg.