Search results
Results from the WOW.Com Content Network
Phage therapy, viral phage therapy, or phagotherapy is the therapeutic use of bacteriophages for the treatment of pathogenic bacterial infections. [1] [2] [3] This therapeutic approach emerged at the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the Second World War.
Phage therapy also allows for the possibility of biofilm penetration in cases where antibiotics are ineffective due to the increased resistance of biofilm-forming pathogens. [9] One major drawback to phage therapy is the evolution of phage-resistant microbes which was seen in a majority of phage therapy experiments aimed to treat sepsis and ...
Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy. [ 5 ] [ 6 ] [ 7 ] It has been in practice for just over 100 years in countries such as Russia and Georgia , but due to the recent clinical attention of antibiotic resistance , Western countries have slowly been integrating phage ...
Bacteriophages were used from the 1920s as an alternative to antibiotics in the former Soviet Union and Central Europe, as well as in France. [7] [8] They are seen as a possible therapy against multi-drug-resistant strains of many bacteria (see phage therapy). [9] [10] [11] [12]
“Phage cocktails” are a form of phage therapy that involves employing at least two phages to target a single bacterial strain, [13] creating a form of therapy with greater ‘depth.’ Phage cocktails are an effective substitute for antibiotics as they create a broader host range and delay the development of phage resistance in bacteria ...
Phage therapy is a good alternative to the use of antibiotics, but some bacteria have CRISPR-Cas systems. Nevertheless, if phages had Acr proteins, they would inhibit the CRISPR-Cas immune system and infect the cell. At the end of the phage reproduction cycle, which takes place inside bacteria, new phages would be released, provoking the cell ...
In the era of increasing antibiotic resistance, corynephages also offer potential in phage therapy, an alternative to traditional antibiotics. Phage therapy exploits the natural ability of phages to infect and lyse specific bacteria, providing a targeted approach to treat bacterial infections, especially those resistant to conventional treatments.
By the late 1990s, Fischetti was exploring the impact of phage lysins, a novel form of antimicrobial ammunition produced by bacterial viruses, bacteriophage, as an alternative to antibiotics, and found it to be a novel solution to target specific antibiotic resistant bacteria.