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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
The serotonin antagonist cyproheptadine is the recommended initial therapy, although there have been no controlled trials demonstrating its efficacy for SS. [ 9 ] [ 69 ] [ 70 ] Despite the absence of controlled trials, there are a number of case reports detailing apparent improvement after people have been administered cyproheptadine. [ 9 ]
AH-1058 is a lipophilic antiarrhythmic calcium channel blocker synthesized by the Pharmaceutical Research Laboratories of Ajinomoto Co., Inc in Kawasaki, Japan. [1] It is derived from cyproheptadine, a compound with known antiserotonic, antihistaminic and calcium channel blocking properties.
The antidepressant mirtazapine, although paradoxically associated with the development of akathisia in some individuals, has demonstrated benefit, [5] as have diphenhydramine, trazodone, benzatropine, cyproheptadine, and beta blockers, particularly propranolol. [2] [4] [12]
All three of these agents, pizotifen, cyproheptadine, and clozapine act as non-selective monoamine receptor antagonists. [10] Pizotifen also fully blocks the effects of serotonergic psychedelics , including LSD , mescaline , 5-MeO-DMT , and DOM , in drug discrimination tests.
After chronic dosing of cyproheptadine (a rather high dose of 8-12mg for 5 days... typical doses are 2-4mg), it reduced growth hormone by over 50%. —Preceding unsigned comment added by 204.111.160.135 20:03, 28 April 2009 (UTC) I have added the reference and data to the adverse effects section of the article.
Episodes is a sitcom created and written by David Crane and Jeffrey Klarik, which premiered on Showtime on January 9, 2011, [1] and on BBC Two on January 10, 2011. The show follows Sean and Beverly Lincoln, a British writing couple who travel to Hollywood to remake their successful show, Lyman's Boys, as an American series. [2]
Funapide (former developmental code names TV-45070 and XEN402) is a novel analgesic under development by Xenon Pharmaceuticals (formerly in partnership with Teva Pharmaceutical Industries) for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain.