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Neurotrophic factors also promote the initial growth and development of neurons in the central nervous system and peripheral nervous system, and they are capable of regrowing damaged neurons in test tubes and animal models. [1] [4] Some neurotrophic factors are also released by the target tissue in order to guide the growth of developing axons.
According to the United States National Library of Medicine's medical subject headings, the term neurotrophin may be used as a synonym for neurotrophic factor, [5] but the term neurotrophin is more generally reserved for four structurally related factors: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). [6]
Brain-derived neurotrophic factor (BDNF), or abrineurin, [5] is a protein [6] that, in humans, is encoded by the BDNF gene. [ 7 ] [ 8 ] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4 /NT-5.
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7873 74840 Ensembl ENSG00000145050 ENSMUSG00000032575 UniProt P55145 Q9CXI5 RefSeq (mRNA) NM_006010 NM_029103 RefSeq (protein) NP_006001 n/a Location (UCSC) Chr 3: 51.39 – 51.39 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Mesencephalic astrocyte-derived neurotrophic factor (MANF), Arginine-rich, mutated in early-stage tumors (ARMET), or arginine-rich protein (ARP) is a ...
18205 Ensembl ENSG00000185652 ENSMUSG00000049107 UniProt P20783 P20181 RefSeq (mRNA) NM_001102654 NM_002527 NM_001164034 NM_001164035 NM_008742 RefSeq (protein) NP_001096124 NP_002518 NP_001157506 NP_001157507 NP_032768 Location (UCSC) Chr 12: 5.43 – 5.52 Mb Chr 6: 126.08 – 126.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurotrophin-3 is a protein that in humans is ...
4803 18049 Ensembl ENSG00000134259 ENSMUSG00000027859 UniProt P01138 P01139 RefSeq (mRNA) NM_002506 NM_001112698 NM_013609 RefSeq (protein) NP_002497 NP_001106168 NP_038637 Location (UCSC) Chr 1: 115.29 – 115.34 Mb Chr 3: 102.38 – 102.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the ...
CNTF: Ciliary neurotrophic factor is another protein that acts as a survival factor for motor neurons. CNTF acts via a receptor complex that includes CNTFRα, GP130, and LIFRβ. Activation of the receptor leads to phosphorylation and recruitment of the JAK kinase, which in turn phosphorylates LIFRβ. LIFRβ acts as a docking site for the STAT ...