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Glioblastoma pre (left) and post (right) resection. Surgery is the first stage of treatment of glioblastoma. An average GBM tumor contains 10 11 cells, which is on average reduced to 10 9 cells after surgery (a reduction of 99%). Benefits of surgery include resection for a pathological diagnosis, alleviation of symptoms related to mass effect ...
The American National Comprehensive Cancer Network's official guidelines list TTFields as an option for the treatment of recurrent glioblastoma, but note substantial disagreement among the members of the expert panel making this recommendation. [2] High-quality evidence for the efficacy of TTFields in oncology is limited.
Temozolomide is an alkylating agent used to treat serious brain cancers; most commonly as second-line treatments for astrocytoma and as the first-line treatment for glioblastoma. [4] [6] [7] Olaparib in combination with temozolomide demonstrated substantial clinical activity in relapsed small cell lung cancer. [8] It is available as a generic ...
Asunercept (INN; development codes APG101 and CAN008) [1] is a soluble CD95-Fc fusion protein which is in clinical development for the treatment of glioblastoma multiforme (GBM) and myelodysplastic syndromes (MDS). [2] Asunercept has been granted orphan drug status for the treatment of GBM and MDS in the EU and the US.
Anaplastic astrocytoma, glioblastoma multiforme, metastatic malignant melanoma: Myelosuppression, Stevens–Johnson syndrome (rare), pneumonitis (rare) and hepatitis (rare). Thiotepa: IV, topical Alkylates DNA. Breast, ovarian, and baldder cancer Myelosupression, embryo-fetal toxicity, hepatotoxicity (rare) [19] Trabectedin: IV Alkylates DNA.
In 2014, Orphan Drug Status was granted by the FDA for glioblastoma multiforme. [6] It is in phase II/III clinical trials for glioblastoma, in phase II clinical trials for non-small cell lung cancer, and in phase I clinical trials for the treatment of other solid tumors. [7] Phase I results were presented at ASCO in 2016. [7]
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