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Cryogenic electron tomography (cryoET) is an imaging technique used to reconstruct high-resolution (~1–4 nm) three-dimensional volumes of samples, often (but not limited to) biological macromolecules and cells.
A drawing of ductal carcinoma in situ in the anatomical context of the whole breast A drawing of a breast duct containing ductal carcinoma in situ. Most of the women who develop DCIS do not experience any symptoms. The majority of cases (80-85%) are detected through screening mammography. The first signs and symptoms may appear if the cancer ...
Combining cryotherapy with immunotherapy enhances the immunostimulating response and has synergistic effects for cancer treatment. [ 6 ] Although, cryoblation and immunotherapy has been used successfully in oncological clinical practice for over 100 years, [ 7 ] [ 8 ] and can treat metastatic disease with curative intent, it has been ignored in ...
Papillary carcinomas of the breast (PCB), also termed malignant papillary carcinomas of the breast, are rare forms of the breast cancers. [1] The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary ...
The overall 5-year survival rate of lobular carcinoma in situ has been estimated to be 97%. [16] LCIS (lobular neoplasia is considered pre-cancerous) is an indicator (marker) identifying women with an increased risk of developing invasive breast cancer. This risk extends more than 20 years.
Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis [1] of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).
Carcinoma in situ (CIS) is a group of abnormal cells. [1] [2] While they are a form of neoplasm, [3] there is disagreement over whether CIS should be classified as cancer.This controversy also depends on the exact CIS in question (e.g., cervical, skin, breast).
The Raunser lab has contributed to developments in cryoEM image processing and cryoET hardware development. [26] They developed SPHIRE [27] (together with Pawel Penczek), which evolved later into TranSPHIRE. [28] The program offers an easy-to-use and versatile image processing suite for the single particle analysis of protein complexes in CryoEM.