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Vasculitic neuropathy is a peripheral neuropathic disease. [ 1 ] [ 2 ] [ 3 ] In a vasculitic neuropathy there is damage to the vessels that supply blood to the nerves . [ 1 ] [ 2 ] [ 3 ] It can be as part of a systemic problem or can exist as a single-organ issue only affecting the peripheral nervous system (PNS).
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Micrograph of a vasculitic neuropathy.Plastic embedded. Toluidine blue stain.. Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies.
Sural nerve biopsy; biopsy is considered for those patients in whom the diagnosis is not completely clear, when other causes of neuropathy (e.g., hereditary, vasculitic) cannot be excluded, or when profound axonal involvement is observed on EMG. Ultrasound of the peripheral nerves may show swelling of the affected nerves. [32] [33] [34]
Non-systemic vasculitic neuropathy (NSVN) [1] Hepatitis C-related cryoglobulinemia neuropathy (CRYOVASC) [1] Hepatitis B-associated PAN [1] Diabetic lumbosacral radiculoplexus neuropathy (DLRPN) [1] Non-diabetic lumbosacral radiculoplexus neuropathy (LRPN) [1] Diabetic cervical-radiculoplexus neuropathy (DCRPN) [1] Diabetic Cranio-Cervico ...
Vasculitis is a group of disorders that destroy blood vessels by inflammation. [2] Both arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis. [3]
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