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The laboratory mouse has been instrumental in investigating the genetics of human disease, including cancer, for over 110 years. [1] The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease.
40% of both human and mouse genomes can be aligned at the nucleotide level. Mice have relatively short gestation periods. Mice take a brief time to reach sexual maturity. Mice have large litter sizes. The availability of hundreds of mutations affecting almost every tissue and aspect of development. Mice may not be an ideal model for breast cancer.
Mouse models of breast cancer metastasis Metadata This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. [1] It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from a patient.
The activated oncogene significantly increases the mouse's susceptibility to cancer, and thus makes the mouse a suitable model for cancer research. [2] [3] OncoMouse was not the first transgenic mouse to be developed for use in cancer research. Ralph L. Brinster and Richard Palmiter had developed such mice previously. However, OncoMouse was the ...
A humanized mouse is a genetically modified mouse that has functioning human genes, cells, tissues and/or organs. [1] Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics.
Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
Human isogenic disease models have been likened to 'patients in a test-tube', since they incorporate the latest research into human genetic diseases and do so without the difficulties and limitations involved in using non-human models. [2] Historically, cells obtained from animals, typically mice, have been used to model cancer-related pathways.