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Invasive urothelial carcinoma is a type of transitional cell carcinoma. It is a type of cancer that develops in the urinary system: the kidney , urinary bladder , and accessory organs. Transitional cell carcinoma is the most common type of bladder cancer and cancer of the ureter , urethra , renal pelvis , the ureters , the bladder , and parts ...
Transitional cell carcinoma is a type of cancer that arises from the transitional epithelium, a tissue lining the inner surface of these hollow organs. [1] It typically occurs in the urothelium of the urinary system; in that case, it is also called urothelial carcinoma.
Around half of affected people have locally advanced disease when they first present. 54–65% of cases are of the urothelial carcinoma type. [ 1 ] Prolonged irritations of the urethra due to urinary catheterization , chronic inflammation due to infection, radiation, diverticula of the urethra , and urethral strictures, may increase the risk of ...
Carcinoma is a type of cancer that occurs in epithelial cells. Transitional cell carcinoma is the leading type of bladder cancer , occurring in 9 out of 10 cases. [ 11 ] It is also the leading cause of cancer of the ureter, urethra, and urachus , and the second leading cause of cancer of the kidney.
They undergo glandular metaplasia, a process in which irritated tissues take on a different form, in this case that of a gland. [1] The main importance is in the findings of test results, in this case histopathology. They must distinguish a benign metaplastic change from the cancerous condition urothelial cell carcinoma. [2]
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Bladder tumors are classified by their appearance under the microscope, and by their cell type of origin. Over 90% of bladder tumors arise from the cells that form the bladder's inner lining, called urothelial cells or transitional cells; the tumor is then classified as urothelial cancer or transitional cell cancer.
They cannot be reliably differentiated from low grade papillary urothelial carcinomas using cytology, [1] and their diagnosis (vis-a-vis low grade papillary urothelial carcinoma) has a poor inter-rater reliability. [2] Pathologic grading and staging tumors are: graded by the degree of cellular atypia (G1->G3), and staged: [citation needed ...