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Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. [5] The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400 ...
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
The biomarkers of Alzheimer's disease are neurochemical indicators used to assess the risk or ... Aβ42 is the initial and major component of amyloid plaque deposits. ...
“By the age of 85 years, only one fifth of those with amyloid plaques develop Alzheimer’s disease. We discovered that what keeps people with amyloid plaques cognitively normal is ...
New research is contradicting previously held views that only neurons secret beta-amyloid that forms toxic plaques, a marker of Alzheimer's disease in the brain. The study points to another ...
APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.
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