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Metformin is an FDA-approved antidiabetic agent that manages high blood sugar levels in type 2 diabetes patients. It reduces glucose absorption from the intestines, lowers liver glucose production, and improves insulin sensitivity. Metformin is recommended with dietary changes and exercise for better results.
Metformin rarely produces hypoglycemia (low blood sugar levels). Metformin does not change how much insulin is secreted and it does not cause hyperinsulinemia (high insulin levels). Fasting insulin levels and the baseline insulin response may decrease. Metformin has a unique mechanism of action and is like no other drug used for diabetes.
Applies to metformin: compounding powder, oral solution, oral suspension extended release, oral tablet, oral tablet extended release. General Gastrointestinal events such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite have been frequently reported during therapy initiation and resolve spontaneously in most cases.
Maximum dose: 2550 mg/day. Initial dose: 500 to 1000 mg orally once a day. Dose titration: Increase in 500 mg increments weekly as tolerated. Maximum dose: 2000 mg/day. Metformin, if not contraindicated, should be considered first line-therapy for the management of type 2 diabetes mellitus.
Metformin Interactions There are 367 drugs known to interact with metformin , along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 24 are major, 334 are moderate, and 9 are minor.
Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Warning. Rarely, metformin may cause an acid health problem (lactic acidosis). The risk is higher in people who have kidney problems, liver problems, heart failure, use alcohol, or take other drugs like topiramate. The risk is also higher in older people (65 or older) and in people who are having surgery, an exam or test with contrast, or other ...
Initial dosage of 500 mg once daily has been suggested by some experts. Increase daily dosage by 500 mg at weekly intervals or by 850 mg at biweekly (every 2 week) intervals up to a maximum of 2.55 g daily given in divided doses. May increase dosage from 500 mg twice daily to 850 mg twice daily after 2 weeks.
Metformin lowers blood glucose (sugar) in your body by lowering liver glucose production, reducing intestinal glucose absorption and improving how well your own insulin works. Metformin (brand name: Glumetza) in the biguanide drug class, is usually the first drug used to help control blood sugar in people with type 2 diabetes.
trouble breathing; feeling dizzy, light-headed, tired, or very weak; stomach pain, vomiting; or. slow or irregular heart rate. Common side effects of MetFORMIN (Eqv-Glucophage XR) may include: low blood sugar; nausea, upset stomach; or. diarrhea. This is not a complete list of side effects and others may occur.