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In immunology, epitope mapping is the process of experimentally identifying the binding site, or epitope, of an antibody on its target antigen (usually, on a protein). [ 1 ] [ 2 ] [ 3 ] Identification and characterization of antibody binding sites aid in the discovery and development of new therapeutics , vaccines , and diagnostics .
This list of protein subcellular localisation prediction tools includes software, databases, and web services that are used for protein subcellular localization prediction. Some tools are included that are commonly used to infer location through predicted structural properties, such as signal peptide or transmembrane helices , and these tools ...
Link alignment results to analysis tools (Primer design, Gel mobility and Maps, Plasmapper, siRNA design Epitope prediction), Save research logs, Create custom toolbars Accession number, GI number, PDB ID, FASTA , drag-drop from external URL from within the user interface
Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches.With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is ...
HSE is used in predicting discontinuous B-cell epitopes. [2] Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. [ 3 ] HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively ...
The part of the antigen that immunoglobulin or antibodies bind to is called a B-cell epitope. [11] B cell epitopes can be divided into two groups: conformational or linear. [11] B cell epitopes are mainly conformational. [12] [13] There are additional epitope types when the quaternary structure is considered. [13]
The basic idea behind reverse vaccinology is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes. Some traits that the genes are monitored for, may indicate antigenicity and include genes that code for proteins with extracellular localization, signal peptides & B cell epitopes. [3]
B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1] After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph. [14] At the SLO, B cell activation begins when the B cell binds to an antigen via its BCR ...