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Naphthoylindoles: Any compound containing a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any ...
Indole-3-carbaldehyde (I3A), also known as indole-3-aldehyde and 3-formylindole, is a metabolite of dietary L-tryptophan which is synthesized by human gastrointestinal bacteria, particularly species of the Lactobacillus genus.
3-Hydroxy-16-methoxy-2,3-dihydrotabersonine is a terpene indole alkaloid produced by Catharanthus roseus. The metabolite is a substrate for 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase (NMT) which transfers a methyl group to the nitrogen of the indole ring forming desacetoxyvindoline . [ 1 ]
6-MeO-THH, or 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a structural isomer of tetrahydroharmine (7-MeO-THH). 6-MeO-THH is mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved), stating that 6-MeO-THH is very similar to the other carbolines. [1]
Moreover, 3-hydroxymethyl-beta-carboline blocks the sleep-promoting effect of flurazepam in rodents and – by itself – can decrease sleep in a dose-dependent manner. [16] Another derivative, methyl-β-carboline-3-carboxylate, stimulates learning and memory at low doses but can promote anxiety and convulsions at high doses. [15]
The Nenitzescu indole synthesis. This reaction was named for its discoverer, Costin Nenițescu, who first reported it in 1929. [1] It can be performed with a number of different combinations of R-groups, which include methyl, methoxy, ethyl, propyl, and H substituents. [2]
Its IUPAC name is 6-methoxy-1,2,3,4-tetrahydro-β-carboline, usually abbreviated as 6-MeO-THBC, and its more common name is a combination of "pineal beta-carboline". [2] The biological activity of this molecule is of interest as a potential free radical scavenger, also known as an antioxidant, [3] and as a monoamine oxidase A inhibitor. [4]
Harmine: C 13 H 12 N 2 O; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole Harmine is a reversible inhibitor of monoamine oxidase A (RIMA). [17] Harmaline: C 13 H 14 N 2 O; 4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole Harmaline is also a RIMA. [18] Harmalol: C 12 H 12 N 2 O; 1-Methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol. Tetrahydroharmine ...