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The binding of low molecular weight ligands can increase the thermal stability of a protein, as described by Daniel Koshland (1958) [4] and Kaj Ulrik Linderstrøm-Lang and Schellman (1959). [5] Almost half of enzymes require a metal ion co-factor . [ 6 ]
The Instability index is a measure of proteins, ... a novel approach for predicting in vivo stability of a protein from its primary sequence". ... 10.1093/protein/4.2 ...
The mature LLO is transferred co-translationally to consensus sequence Asn residues in the nascent protein, and is further modified by trimming and re-building in the Golgi. [9] Deficiencies in the genes involved in N-linked glycosylation constitute the molecular background of most CDGs. [10] Type I defects involve the synthesis and transfer of ...
In computational biology, protein pK a calculations are used to estimate the pK a values of amino acids as they exist within proteins.These calculations complement the pK a values reported for amino acids in their free state, and are used frequently within the fields of molecular modeling, structural bioinformatics, and computational biology.
A mass spectrometer used for high throughput protein analysis. Protein mass spectrometry refers to the application of mass spectrometry to the study of proteins.Mass spectrometry is an important method for the accurate mass determination and characterization of proteins, and a variety of methods and instrumentations have been developed for its many uses.
Dehydration is a recognized factor affecting BIA measurements, as it causes an increase in the body's electrical resistance, so has been measured to cause a 5 kg underestimation of fat-free mass i.e. an overestimation of body fat. [4] Body-fat measurements are lower when measurements are taken shortly after consumption of a meal, causing a ...
Risk factors associated with steatosis are varied, and may include diabetes mellitus, protein malnutrition, hypertension, [4] cell toxins, obesity, [5] anoxia, [2] and sleep apnea. [6] Steatosis reflects an impairment of the normal processes of synthesis and elimination of triglyceride fat. Excess lipid accumulates in vesicles that displace the ...
Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation. [10] [11] [12] Adiponectin is secreted from adipose tissue (and also from the placenta in pregnancy [13]) into the bloodstream and is very abundant in plasma relative to many hormones.