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These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
[14] [15] [16] The most common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation. [14] [17] [18] [19] [29] It was approved for medical use in the US in 2017. [14] [30] In 2022, it was the 48th most commonly prescribed medication in the United States, with more than 13 million prescriptions. [31] [32]
Gastroenteritis, also known as infectious diarrhea, is an inflammation of the gastrointestinal tract including the stomach and intestine. [8] Symptoms may include diarrhea , vomiting , and abdominal pain . [ 1 ]
Using the cerumenolytic hydrogen peroxide as an example, no adverse effects are expected with overdose of an otic administered preparation. [5] The average middle ear volume is 0.4 mL, which limits otic accumulation in overdose. [6]
Side effects from using ear drops used to remove ear wax are uncommon, but may result in discomfort, irritation, or pain. [5] Antibiotic ear drops may cause ear discomfort, pain, or itching. [1] When cold ear drops are used, it may cause brief but severe dizziness and/or vertigo. [6]
Signs and symptoms of CDI range from mild diarrhea to severe life-threatening inflammation of the colon. [16]In adults, a clinical prediction rule found the best signs to be significant diarrhea ("new onset of more than three partially formed or watery stools per 24-hour period"), recent antibiotic exposure, abdominal pain, fever (up to 40.5 °C or 105 °F), and a distinctive foul odor to the ...
[14] [6] [5] [21] In any case, phenylpropanolamine can produce amphetamine-like psychostimulant effects at very high doses. [21] [6] [5] Phenylpropanolamine is more lipophilic than structurally related sympathomimetics with hydroxyl groups on the phenyl ring like epinephrine (adrenaline) and phenylephrine and has greater brain permeability than ...
COX-2 selective inhibitors have fewer gastrointestinal side effects, but promote thrombosis, and some of these agents substantially increase the risk of heart attack. As a result, certain COX-2 selective inhibitors—such as rofecoxib —are no longer used due to the high risk of undiagnosed vascular disease . [ 11 ]
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