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Vonicog alfa, sold under the brand names Vonvendi and Veyvondi, is a medication used to control bleeding in adults with von Willebrand disease (an inherited bleeding disorder). [6] [5] [7] [8] It is a recombinant von Willebrand factor. [6] [5] The most common adverse reactions are generalized itching, vomiting, nausea, dizziness, and vertigo. [6]
The Lionel Corporation used the 2-6-4 wheel arrangement in many of its model steam locomotives, including the 2037 used in the infamous pastel-coloured Girls' Train. [9] Their 2-6-4 model was based on the Pennsylvania Railroad’s K4 class pacific , even though this was a 4-6-2 rather than a 2-6-4.
Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. [1] In hemophilia A and von Willebrand disease, it should only be used for mild to moderate cases. [ 1 ]
The first 2-6-6-4s built in the United States were for the Pittsburgh and West Virginia Railroad, and these were not high-speed locomotives but rather mountain engines. They received three in 1934 and four more in 1937 and operated the 2-6-6-4s until 1953. The next of the type was a class of ten ordered by the Seaboard Air Line in 1935 and 1937 ...
The most prominent vasopressin analogues include desmopressin (dDAVP), terlipressin, and selepressin, each with distinct pharmacological profiles and clinical uses. Desmopressin, a V2 receptor agonist, is primarily used for treating diabetes insipidus and certain bleeding disorders. [ 3 ]
In addition, desmopressin (DDAVP) is known to be effective in people with von Willebrand's disease, [17] [18] including people with valvular heart disease. [19] [20] Desmopressin stimulates release of von Willebrand factor from blood vessel endothelial cells by acting on the V2 receptor, which leads to decreased breakdown of Factor VIII.
Type 3 von Willebrand disease is when dogs have low or no von Willebrand factor at all – less than 1% of normal. This slows clotting significantly, meaning this is the most severe form of von ...
The technical assignment, issued in the spring of 1930, for an alternative preliminary design of a Soviet high-speed freight steam locomotive, with more than five moving axles in one rigid frame, provided for a maximum axial load on the rails of 20 tons, that is, the same as for the preliminary design of a Soviet steam locomotive type 1-5-1 ...
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